PUBLICATIONS

Maynard J, Segatori L. Tissue, cell, and pathway engineering: Recent innovations in biomedical technologies. Current Opinion in Biotechnology. 2023, 83: 102981 

Jayanthi B, Jayanthi S, Segatori L*. Design of oscillatory networks through post-translational control of network components. Synthetic Biology and Engineering. 2023 1(1) 10004. doi:10.35534/sbe.2023.10004

Larkin J, Jayanthi B, Segatori L, Ball Z. Boronic Acid Resin for Selective Immobilization of Canonically Encoded Proteins. Biomacromolecules 2023, 24, 5, 2196–2202. doi.org/10.1021/acs.biomac.3c00096

Bachhav B, de Rossi J, Llanos Carlos, Segatori L*. Cell factory engineering: challenges and opportunities for synthetic biology applications. Biotechnology and Bioengineering. 2023 Mar 1. doi: 10.1002/bit.28365.

de Rossi J, Arefeayne Y, Robinson A, Segatori L*. Emerging technologies for genetic control systems in cellular therapies. Current Opinion in Biotechnology. 2022 Dec;78:102833. doi: 10.1016/j.copbio.2022.102833.

Bachhav B, Origel C, Arefeayne Y, Segatori L*. A platform technology for monitoring the unfolded protein response. Methods in Molecular Biology. 2022;2378:45-67. doi: 10.1007/978-1-0716-1732-8_4.

Jayanthi B, Bachhav B, Wan Z, Martinez S M, Segatori L*. A platform for post-translational and spatiotemporal control of cellular proteins. Synthetic Biology. 2021 Feb 2;6(1):ysab002. doi: 10.1093/synbio/ysab002. eCollection 2021.

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. 

Barrios, D, Segatori L*. Open question: how do engineered nanomaterials affect our cells? BMC Biology. 2020 Nov 24;18(1):176. doi: 10.1186/s12915-020-00922-0

Whitehead T, Banta S, Bentley W, Chan C, Clark DS, Hoesli C, Jewett M, Junker B, Koffas, M, Kshirsagar R, Lewis A, Li C, Maranas C, Papoutsakis T, Prather K, Schaffer S, Segatori L and Wheeldon I. The importance and future of biochemical engineering. Biotechnology and Bioengineering. 2020 Aug;117(8):2305-2318. doi: 10.1002/bit.27364.

Origel C, Bachhav B, Patibanda S, Yang A, Segatori L*. A gene signal amplifier platform for monitoring the unfolded protein response. Nature Chemical Biology. 2020 May;16(5):520-528. doi: 10.1038/s41589-020-0497-x.

Zeng Y, Bhagyashree B, Zhao W, Nguyen T, Segatori L*. A hysteretic circuit for detection of proteasomal degradation in mammalian cells.  ACS Synth Biol. 2019 Sep 20;8(9):2025-2035. doi: 10.1021/acssynbio.9b00074.

Legaspi S, Segatori L*. Aggregation behavior of nanoparticle-peptide systems affects autophagy. Bioconjugate chemistry. 2019 Jul 17;30(7):1986-1997. doi: 10.1021/acs.bioconjchem.9b00266.

Jayanthi BEK, Zhao W, Segatori L*. Input-dependent post-translational control of the reporter output enhances dynamic resolution of mammalian signaling systems. Methods Enzymol 2019. 2019;622:1-27. doi: 10.1016/bs.mie.2019.02.013.

Atkinson J, Wu B, Segatori L*, Silberg JJ*. Overcoming component limitations in synthetic biology through transposon-mediated protein engineering. Methods Enzymol 2019 2019;621:191-212. doi: 10.1016/bs.mie.2019.02.014.

Popp L and Segatori L*. Zinc oxide particles induce activation of the lysosome-autophagy system. ACS Omega. 2019, 4 (1), 573–581. doi: 10.1021/acsomega.8b01497.

Zhao W, Bachhav B, McWhite C, Segatori L*. A yeast selection system for the detection of proteasomal activation. Protein Eng Des Sel. 2018. Nov 1;31(11):437-445. doi: 10.1093/protein/gzz006.

di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM, Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018 Dec;20(12):1370-1377. doi: 10.1038/s41556-018-0228-7.

Popp L, Tran V, Patel R, Segatori L*. Autophagic response to cellular exposure to titanium dioxide nanoparticles. Acta Biomater. 2018 Oct 1;79:354-363. doi: 10.1016/j.actbio.2018.08.021

Zeng, Y, Jones A, Thomas E, Nassif B, Silberg J, Segatori L*. A split transcriptional repressor that links protein solubility to an orthogonal genetic circuit. ACS Synth Biol. 2018. Sep 21;7(9):2126-2138. doi: 10.1021/acssynbio.8b00129. 

Ohata J, Zeng Y, Segatori L, Ball ZT. A Naturally Encoded Dipeptide Handle for Bioorthogonal Chan-Lam Coupling. Angew Chem Int Ed Engl. 2018 Apr 3;57(15):4015-4019. doi: 10.1002/anie.201800828. PMID: 29417733

Zhao W, Pferdehirt L, Segatori L. Quantitatively Predictable Control of Cellular Protein Levels through Proteasomal Degradation. ACS Synth Biol. 2018 Feb 16;7(2):540-552. doi: 10.1021/acssynbio.7b00325. Epub 2017 Nov 7. PMID: 29061039

Popp L, Gomez E, Orji W, Ho M, Suh J, Segatori L. TFEB-mediated activation of the lysosome-autophagy system affects the transduction efficiency of adeno-associated virus 2. Virology. 2017 Oct;510:1-8. doi: 10.1016/j.virol.2017.06.030. Epub 2017 Jul 5. PMID: 28688268

Pandey N, Kuypers BE, Nassif B, Thomas EE, Alnahhas RN, Segatori L, Silberg JJ. Tolerance of a Knotted Near-Infrared Fluorescent Protein to Random Circular Permutation. Biochemistry. 2016 Jul 12;55(27):3763-73. doi: 10.1021/acs.biochem.6b00258. Epub 2016 Jun 29. PMID: 27304983

Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. PMID: 26799652

Song W, Popp L, Yang J, Kumar A, Gangoli VS, Segatori L.The autophagic response to polystyrene nanoparticles is mediated by transcription factor EB and depends on surface charge. J Nanobiotechnology. 2015 Nov 23;13:87. doi: 10.1186/s12951-015-0149-6. PMID: 26596266

Popp L, Segatori L. Differential autophagic responses to nano-sized materials. Curr Opin Biotechnol. 2015 Dec;36:129-36. doi: 10.1016/j.copbio.2015.08.016. Review. PMID: 26340102 

Kilpatrick K, Zeng Y, Hancock T, Segatori L. Genetic and chemical activation of TFEB mediates clearance of aggregated α-synuclein. PLoS One. 2015 Mar 19;10(3):e0120819. doi: 10.1371/journal.pone.0120819. eCollection 2015. PMID: 25790376

Song W, Soo Lee S, Savini M, Popp L, Colvin VL, Segatori L. Ceria nanoparticles stabilized by organic surface coatings activate the lysosome-autophagy system and enhance autophagic clearance. ACS Nano. 2014 Oct 28;8(10):10328-42. doi: 10.1021/nn505073u. PMID:25315655

Segatori L. Impairment of homeostasis in lysosomal storage disorders. IUBMB Life. 2014 Jul;66(7):472-7. doi: 10.1002/iub.1288. Epub 2014 Jul 18. Review. PMID: 25044960

Wang J, Segatori L, Biswal SL. Probing the association of triblock copolymers with supported lipid membranes using microcantilevers. Soft Matter. 2014 Sep 14;10(34):6417-24. doi: 10.1039/c4sm00928b. PMID:24978842 

Zhao W, Bonem M, McWhite C, Silberg JJ, Segatori L. Sensitive detection of proteasomal activation using the Deg-On mammalian synthetic gene circuit. Nat Commun. 2014 Apr 8;5:3612. doi: 10.1038/ncomms4612.PMID: 24710080

Song W, Wang F, Lotfi P, Sardiello M, Segatori L. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22. doi: 10.1074/jbc.M113.506246. Epub 2014 Feb 20. PMID: 24558044

Wang J, Morton MJ, Elliott CT, Karoonuthaisiri N, Segatori L, Biswal SL. Rapid detection of pathogenic bacteria and screening of phage-derived peptides using microcantilevers. Anal Chem. 2014 Feb 4;86(3):1671-8. doi: 10.1021/ac403437x. PMID: 24417655

Wang J, Liu KW, Segatori L, Biswal SL. Lipid bilayer phase transformations detected using microcantilevers.J Phys Chem B. 2014 Jan 9;118(1):171-8. doi: 10.1021/jp4095112. Epub 2013 Dec 24. PMID:24345294

Lee SS, Song W, Cho M, Puppala HL, Nguyen P, Zhu H, Segatori L, Colvin VL. Antioxidant properties of cerium oxide nanocrystals as a function of nanocrystal diameter and surface coating. ACS Nano. 2013 Nov 26;7(11):9693-703. doi: 10.1021/nn4026806. PMID: 24079896

Mauri V, Lotfi P, Segatori L, Sardiello M. A rapid and sensitive method for measuring N-acetylglucosaminidase activity in cultured cells. PLoS One. 2013 Jun 28;8(6):e68060. doi: 10.1371/journal.pone.0068060. PMID: 23840811

Wang F, Segatori L. Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding. PLoS One. 2013 Apr 19;8(4):e61418. doi: 10.1371/journal.pone.0061418. Print 2013. PMID: 23620750

Kilpatrick K, Novoa JA, Hancock T, Guerriero CJ, Wipf P, Brodsky JL, Segatori L. Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells. ACS Chem Biol. 2013 Jul 19;8(7):1460-8. doi: 10.1021/cb400017h.  PMID: 23594135

 Song W, Wang F, Savini M, Ake A, di Ronza A, Sardiello M, Segatori L.TFEB regulates lysosomal proteostasis. Hum Mol Genet. 2013 May 15;22(10):1994-2009. doi: 10.1093/hmg/ddt052. PMID: 23393155

 Cook NP, Kilpatrick K, Segatori L, Martí AA. Detection of α-synuclein amyloidogenic aggregates in vitro and in cells using light-switching dipyridophenazine ruthenium(II) complexes. J Am Chem Soc. 2012 Dec 26;134(51):20776-82. doi: 10.1021/ja3100287. PMID: 23237404

Kothawala A, Kilpatrick K, Novoa JA, Segatori L. Quantitative analysis of α-synuclein solubility in living cells using split GFP complementation. PLoS One. 2012;7(8):e43505. doi: 10.1371/journal.pone.0043505. PMID: 22927976 

Mathieu JM, Wang F, Segatori L, Alvarez PJ. Increased resistance to oxysterol cytotoxicity in fibroblasts transfected with a lysosomally targeted Chromobacterium oxidase. Biotechnol Bioeng. 2012 Sep;109(9):2409-15. doi: 10.1002/bit.24506. Epub 2012 Apr 8. PMID: 22447444

Wang F, Song W, Brancati G, Segatori L. Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases. J Biol Chem. 2011 Dec 16;286(50):43454-64. doi: 10.1074/jbc.M111.274332. PMID: 22006919

Wang F, Chou A, Segatori L. Lacidipine remodels protein folding and Ca 2+ homeostasis in Gaucher’s disease fibroblasts: a mechanism to rescue mutant glucocerebrosidase. Chem Biol. 2011 Jun 24;18(6):766-76. doi: 10.1016/j.chembiol.2011.04.008.PMID: 21700212

Wang F, Agnello G, Sotolongo N, Segatori L. Ca2+ homeostasis modulation enhances the amenability of L444P glucosylcerebrosidase to proteostasis regulation in patient-derived fibroblasts. ACS Chem Biol. 2011 Feb 18;6(2):158-68. doi: 10.1021/cb100321m. PMID: 21043486

Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR 3rd, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell. 2008 Sep 5;134(5):769-81. doi: 10.1016/j.cell.2008.06.037. PMID: 18775310